Endocrine Abstracts

Receptor-activator of nuclear factor kB (RANK), its ligand RANKL and the soluble decoy receptor osteoprotegerin (OPG) are the key regulators of osteoclast differentiation and bone remodelling. Although there is a strong association between osteoporosis and skeletal muscle atrophy, the functional relevance of a particular biological pathway that regulates synchronously bone and skeletal muscle physiopathology remain elusive. We thus hypothesized that RANK/RANKL/OPG, which is a ...